{"id":23,"date":"2026-01-07T00:09:23","date_gmt":"2026-01-07T00:09:23","guid":{"rendered":"https:\/\/www.acylerate.ac.uk\/?page_id=23"},"modified":"2026-05-01T15:20:38","modified_gmt":"2026-05-01T14:20:38","slug":"home","status":"publish","type":"page","link":"https:\/\/www.acylerate.ac.uk\/","title":{"rendered":"Home"},"content":{"rendered":"\n<p class=\"is-style-text-subtitle has-large-font-size is-style-text-subtitle--1 wp-block-paragraph\">Welcome to the AcylERATE website. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-align-left is-style-text-display has-large-font-size is-style-text-display--2 wp-block-paragraph\">AcylERATE is a 5-year cross-institutional project funded by the BBSRC sLoLa programme to investigate dynamic S-acylation using a multi-disciplinary approach, with the objective of delivering new insight into the physiological role of this post-translational modification in cell functions.&nbsp; The project will develop and implement tools and technologies to build a holistic understanding of the mechanisms and outcomes of dynamic S-acylation.<\/p>\n\n\n\n<p class=\"is-style-text-subtitle has-large-font-size is-style-text-subtitle--3 wp-block-paragraph\">The project brings together experts in S-acylation and key enabling technologies and the work will accelerate progress in this field of research.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Latest News<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-794e3cfa wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-style-default is-layout-flex wp-container-core-columns-is-layout-794e3cfa wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><ul class=\"wp-block-latest-posts__list has-dates wp-block-latest-posts is-layout-flow wp-block-latest-posts-is-layout-flow\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=294\">Progress Update in Coventry<\/a><time datetime=\"2026-09-25T10:40:30+01:00\" class=\"wp-block-latest-posts__post-date\">September 25, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\">\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"675\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-1024x675.jpg\" alt=\"\" class=\"wp-image-282 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-1024x675.jpg 1024w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-300x198.jpg 300w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-768x507.jpg 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-1536x1013.jpg 1536w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Team-Photo-Coventry-2048x1351.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>The AcylERATE team met at Coventry University on 18th September 2026 for a productive day of presentations, project updates and planning.<\/summary>\n<p class=\"wp-block-paragraph\">Thanks go to the team at Coventry University for hosting this in-person event and to all those who prepared and gave presentations during the day.<\/p>\n<\/details>\n<\/div><\/div>\n<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=292\">Success at FASEB 2026<\/a><time datetime=\"2026-09-25T10:31:21+01:00\" class=\"wp-block-latest-posts__post-date\">September 25, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\">\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"752\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-1024x752.jpg\" alt=\"\" class=\"wp-image-283 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-1024x752.jpg 1024w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-300x220.jpg 300w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-768x564.jpg 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-1536x1127.jpg 1536w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/FASEB-prize-winners-2048x1503.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Congratulations to Anne Schuhmacher from Imperial College London for winning the prize at FASEB 2026 conference for best poster.<\/summary>\n<p class=\"wp-block-paragraph\">The AcylERATE team presented several talks at FASEB (Federation of American Societies for Experimental Biology) 2026 including invited presentations from Amina Nigmatulin (Imperial College London) and Gemma MacDonald (Strathclyde).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/details>\n<\/div><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>Bifunctional Depalmitoylators: Towards Programmable Control of Protein Lipidation<\/em>, Will Fuller, University of Glasgow, UK<\/li>\n\n\n\n<li><em>Defining zDHHC9\u2013RAS Interactions and the Role of GCP16 in Substrate Recognition,<\/em>\u00a0Gemma MacDonald, Strathclyde University, UK<\/li>\n\n\n\n<li>Exploring protein S-acylation through chemical biology, Ed Tate, Imperial College London, UK<\/li>\n\n\n\n<li><em>SAPPHIRE: A high-throughput proteomics platform for profiling dynamic protein S-acylationusing phosphonate handles<\/em>, Amina Nigmatulin, Imperial College London, UK<\/li>\n\n\n\n<li><em>Substrate specificity of the ABHD deacylases<\/em>, Jennifer Greaves, Coventry University, UK<\/li>\n\n\n\n<li>Poster. Anne Schumacher, Imperial College London, UK<\/li>\n\n\n\n<li>Poster.  Anna Scott, Strathclyde University, UK<\/li>\n\n\n\n<li>Poster. Laura Bartkova, Oxford University, UK<\/li>\n\n\n\n<li>Poster. Valerio Di Domenico, Oxford University, UK<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=289\">Prof Ari Sadanandom Seminar: Understanding the SUMO code for adaptive responses in plants<\/a><time datetime=\"2026-09-25T10:15:58+01:00\" class=\"wp-block-latest-posts__post-date\">September 25, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\">\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Uri-Seminar-1024x576.png\" alt=\"\" class=\"wp-image-284 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Uri-Seminar-1024x576.png 1024w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Uri-Seminar-300x169.png 300w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Uri-Seminar-768x432.png 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/09\/Uri-Seminar.png 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Ari Sadanandom discussed his work on SUMOylation in plants, focusing on how SUMO modification regulates protein function, signalling and developmental responses to environmental cues. <\/summary>\n<p class=\"wp-block-paragraph\">He highlighted experimental and computational approaches for studying SUMO-dependent signalling, including tools for detecting SUMOylated proteins, predicting candidate SUMOylation sites, and identifying proteins that interact through SUMO-interacting motifs. He also discussed the expansion and diversification of SUMO proteases in plants, consistent with increasing complexity in SUMO-dependent regulation. A key example was the SUMOylation of ARF7, which regulates root hydropatterning by controlling auxin-response activity and recruitment of the Aux\/IAA repressor IAA3, thereby helping position lateral root formation in response to local water availability. The SUMO proteases OTS1\/2 are also relevant to this pathway. Ari also described newer work showing that reactive oxygen species\/redox signalling can regulate IAA3\/SHY2 multimerisation, linking water-stress responses to auxin signalling and lateral root development. Overall, the seminar emphasised how SUMO protease expression, localisation and activity help determine where and when SUMO-dependent regulatory events occur.<\/p>\n<\/details>\n<\/div><\/div>\n\n\n<div class=\"wp-block-post-date\"><time datetime=\"2026-09-16T15:00:00\">September 16, 2026<\/time><\/div><\/div><\/li>\n<\/ul><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.acylerate.ac.uk\/?page_id=43\">View all<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the AcylERATE website. AcylERATE is a 5-year cross-institutional project funded by the BBSRC sLoLa programme to investigate dynamic S-acylation using a multi-disciplinary approach, with the objective of delivering new insight into the physiological role of this post-translational modification in cell functions.&nbsp; The project will develop and implement tools and technologies to build a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":270,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-23","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23"}],"version-history":[{"count":14,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":259,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions\/259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/media\/270"}],"wp:attachment":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}