{"id":23,"date":"2026-01-07T00:09:23","date_gmt":"2026-01-07T00:09:23","guid":{"rendered":"https:\/\/www.acylerate.ac.uk\/?page_id=23"},"modified":"2026-05-01T15:20:38","modified_gmt":"2026-05-01T14:20:38","slug":"home","status":"publish","type":"page","link":"https:\/\/www.acylerate.ac.uk\/","title":{"rendered":"Home"},"content":{"rendered":"\n<p class=\"is-style-text-subtitle has-large-font-size is-style-text-subtitle--1 wp-block-paragraph\">Welcome to the AcylERATE website. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-align-left is-style-text-display has-large-font-size is-style-text-display--2 wp-block-paragraph\">AcylERATE is a 5-year cross-institutional project funded by the BBSRC sLoLa programme to investigate dynamic S-acylation using a multi-disciplinary approach, with the objective of delivering new insight into the physiological role of this post-translational modification in cell functions.&nbsp; The project will develop and implement tools and technologies to build a holistic understanding of the mechanisms and outcomes of dynamic S-acylation.<\/p>\n\n\n\n<p class=\"is-style-text-subtitle has-large-font-size is-style-text-subtitle--3 wp-block-paragraph\">The project brings together experts in S-acylation and key enabling technologies and the work will accelerate progress in this field of research.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Latest News<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-794e3cfa wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<div class=\"wp-block-columns is-style-default is-layout-flex wp-container-core-columns-is-layout-794e3cfa wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><ul class=\"wp-block-latest-posts__list has-dates wp-block-latest-posts\"><li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=272\">Prof Bryan Dickinson Seminar: Chemical tools to probe signaling by protein lipidation<\/a><time datetime=\"2026-05-26T11:44:50+01:00\" class=\"wp-block-latest-posts__post-date\">May 26, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\"><!-- wp:media-text {\"mediaId\":277,\"mediaLink\":\"https:\/\/www.acylerate.ac.uk\/?attachment_id=277\",\"linkDestination\":\"none\",\"mediaType\":\"image\"} -->\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/06\/Dickinson-Seminar-1024x576.png\" alt=\"\" class=\"wp-image-277 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/06\/Dickinson-Seminar-1024x576.png 1024w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/06\/Dickinson-Seminar-300x169.png 300w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/06\/Dickinson-Seminar-768x432.png 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/06\/Dickinson-Seminar.png 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\"><!-- wp:details -->\n<details class=\"wp-block-details\"><summary>The team welcomed Professor Bryan Dickinson (The University of Chicago, and member of the sLoLa Strategic Advisory Board) to present a seminar entitled <strong>\u201cChemical tools to probe signalling by protein lipidation.\u201d<\/strong>\u00a0<\/summary><!-- wp:paragraph {\"placeholder\":\"Type \/ to add a hidden block\"} -->\n<p><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:details -->\n<details class=\"wp-block-details\"><summary>Bryan discussed his team\u2019s innovative research developing activity-based probes for thioesterase activity and inhibitors of zDHHC enzymes, as well as the use of the thioesterase probes to explore changes in S-acylation that occur in response to growth factors and other stimuli. He described novel research on the S-acylation of ERK1\/2 and the downstream effects on gene expression, alongside the use of chemical probes to investigate the function of mitochondrial thioesterases and their role in regulating Peroxiredoxin (PRDX) proteins and mitochondrial redox buffering capacity. The seminar highlighted the power of modern chemical biology approaches for elucidating the functional consequences of S-acylation.<\/summary><!-- wp:paragraph {\"placeholder\":\"Type \/ to add a hidden block\"} -->\n<p><\/p>\n<!-- \/wp:paragraph --><\/details>\n<!-- \/wp:details --><\/details>\n<!-- \/wp:details --><\/div><\/div>\n<!-- \/wp:media-text -->\n\n<!-- wp:post-date {\"metadata\":{\"bindings\":{\"datetime\":{\"source\":\"core\/post-data\",\"args\":{\"field\":\"date\"}}}},\"className\":\"wp-block-post-date__modified-date\"} \/-->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph --><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=245\">Maurine E Linder Seminar: Fatty acyl tales<\/a><time datetime=\"2026-03-31T23:12:56+01:00\" class=\"wp-block-latest-posts__post-date\">March 31, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\"><!-- wp:media-text {\"mediaId\":248,\"mediaLink\":\"https:\/\/www.acylerate.ac.uk\/?attachment_id=248\",\"mediaType\":\"image\"} -->\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"582\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/04\/Linder-Seminar-1024x582.png\" alt=\"\" class=\"wp-image-248 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/04\/Linder-Seminar-1024x582.png 1024w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/04\/Linder-Seminar-300x171.png 300w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/04\/Linder-Seminar-768x437.png 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/04\/Linder-Seminar.png 1046w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure><div class=\"wp-block-media-text__content\"><!-- wp:paragraph {\"placeholder\":\"Content\u2026\",\"className\":\"is-style-default\"} -->\n<p class=\"is-style-default\"><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:details -->\n<details class=\"wp-block-details\"><summary>The sLoLa team and their wider collaborators welcomed Professor Maurine Linder (Cornell University) for an online seminar on Tuesday 31 March 2026.<\/summary><!-- wp:paragraph {\"placeholder\":\"Type \/ to add a hidden block\"} -->\n<p>Maurine is one of the pioneers of the S-acylation field and the chair of our Strategic Advisory Board. Maurine delivered a fascinating historical perspective on S-acylation, highlighting how early biochemical discoveries have shaped the field as it stands today.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>With many members of the sLoLa team new to the area, the discussion of early challenges and breakthroughs in identifying S-acylation and deacylation enzymes provided an excellent introduction to the landmark studies that defined the field.<\/p>\n<!-- \/wp:paragraph --><\/details>\n<!-- \/wp:details --><\/div><\/div>\n<!-- \/wp:media-text -->\n\n<!-- wp:post-date {\"metadata\":{\"bindings\":{\"datetime\":{\"source\":\"core\/post-data\",\"args\":{\"field\":\"date\"}}}},\"className\":\"wp-block-post-date__modified-date\"} \/-->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph --><\/div><\/li>\n<li><a class=\"wp-block-latest-posts__post-title\" href=\"https:\/\/www.acylerate.ac.uk\/?p=235\">PhD Success<\/a><time datetime=\"2026-03-19T04:48:38+00:00\" class=\"wp-block-latest-posts__post-date\">March 19, 2026<\/time><div class=\"wp-block-latest-posts__post-full-content\"><!-- wp:media-text {\"mediaId\":232,\"mediaLink\":\"https:\/\/www.acylerate.ac.uk\/?attachment_id=232\",\"mediaType\":\"image\"} -->\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"1024\" src=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-768x1024.png\" alt=\"\" class=\"wp-image-232 size-full\" srcset=\"https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-768x1024.png 768w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-225x300.png 225w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-1152x1536.png 1152w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-1536x2048.png 1536w, https:\/\/www.acylerate.ac.uk\/wp-content\/uploads\/2026\/03\/Rocio-PhD-1-scaled.png 1920w\" sizes=\"auto, (max-width: 768px) 100vw, 768px\" \/><\/figure><div class=\"wp-block-media-text__content\"><!-- wp:paragraph {\"placeholder\":\"Content\u2026\",\"className\":\"is-style-default\"} -->\n<p class=\"is-style-default\"><\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:details -->\n<details class=\"wp-block-details\"><summary>Congratulations to Rocio White who has recently been awarded her PhD.<\/summary><!-- wp:paragraph {\"placeholder\":\"Type \/ to add a hidden block\"} -->\n<p>Rocio completed her doctoral studies at the University of British Columbia, investigating the role of the <em>S<\/em>-acylating enzyme, ZDHHC9, in oligodendrocyte maturation, function, and neuronal development.<\/p>\n<!-- \/wp:paragraph -->\n\n<!-- wp:paragraph -->\n<p>She will begin working on the AcylERATE project as a PDRA in the Tate Group in April 2026.<\/p>\n<!-- \/wp:paragraph --><\/details>\n<!-- \/wp:details --><\/div><\/div>\n<!-- \/wp:media-text -->\n\n<!-- wp:post-date {\"metadata\":{\"bindings\":{\"datetime\":{\"source\":\"core\/post-data\",\"args\":{\"field\":\"modified\"}}}},\"className\":\"wp-block-post-date__modified-date\"} \/-->\n\n<!-- wp:paragraph -->\n<p><\/p>\n<!-- \/wp:paragraph --><\/div><\/li>\n<\/ul><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/www.acylerate.ac.uk\/?page_id=43\">View all<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Welcome to the AcylERATE website. AcylERATE is a 5-year cross-institutional project funded by the BBSRC sLoLa programme to investigate dynamic S-acylation using a multi-disciplinary approach, with the objective of delivering new insight into the physiological role of this post-translational modification in cell functions.&nbsp; The project will develop and implement tools and technologies to build a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":270,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-23","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=23"}],"version-history":[{"count":14,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":259,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/23\/revisions\/259"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=\/wp\/v2\/media\/270"}],"wp:attachment":[{"href":"https:\/\/www.acylerate.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}